Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer

"These results, combined with the patient satisfaction with the relative ease of providing blood rather than a solidtissue sample, suggest a clinical strategy of pursuing plasma NGS first, then tissue NGS if plasma NGS cannot detect relevant mutations."


Bishal Gyawali, MD, PhD; Howard (Jack) West, MD
Editorial

with tissue genotyping for targetable alterations before first-line NSCLC therapy

Study Overview

Published in JAMA Oncology, this large, prospective study enrolled 323 patients with advanced NSCLC and concluded that routine use of Guardant360 can increase the likelihood of finding targetable mutations.

Key findings

44% of eligible patients

were unable to get complete genomic results from tissue biopsy

2x as many patients

had targetable alterations detected by Guardant360 and tissue testing (n=82) versus tissue testing alone (n=47)

86% of patients

had a response or stable disease based on RECIST criteria

Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer

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